Virulate 300mg/600mg Tablet
PDF Leaflet Revision Date: 06 April 2022
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of HIV infection in adults and adolescents from 12 years of age, weighing at least 40 kg.
Dosage (summary)
One tablet once daily for adults and adolescents weighing 40 kg or more.
Special Populations
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
Not recommended during pregnancy or lactation due to potential risks.
Key Drug Interactions
- Ethanol may increase abacavir AUC by 41%
- Trimethoprim increases lamivudine exposure by 40%
Contraindications
- Hypersensitivity to abacavir or lamivudine
- Moderate and severe hepatic impairment
- Children below 12 years of age (weighing less than 40 kg)
Common side effects
- Headache
- Nausea
- Abdominal pain
- Vomiting
- Diarrhoea
- Rash
Counselling Points
- Inform patients about hypersensitivity risks and symptoms.
- Advise against restarting treatment after hypersensitivity.
- Monitor for signs of lactic acidosis.
Serious warnings
- Risk of hypersensitivity reactions
- Lactic acidosis
- Severe hepatomegaly with steatosis
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