Akeega 50 mg /500 mg & 100 mg /500 mg Film coated tablet
PDF Leaflet Revision Date: 26 August 2025
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment for male adults with metastatic castration-resistant prostate cancer (mCRPC) with BRCA gene alterations.
Dosage (summary)
200 mg niraparib/1000 mg abiraterone acetate daily on an empty stomach.
Special Populations
- Elderly
- Hepatic impairment
- Renal impairment
Pregnancy & Breastfeeding
Not for use in women; potential for fetal harm; handle with gloves.
Key Drug Interactions
- Strong CYP3A4 inducers
- CYP2D6 substrates
- CYP2C8 substrates
Contraindications
- Hypersensitivity to components
- Moderate to severe hepatic impairment
- Women
Common side effects
- Anaemia
- Hypertension
- Thrombocytopenia
- Nausea
- Fatigue
Counselling Points
- Take on an empty stomach
- Monitor blood pressure
- Report signs of infection
Serious warnings
- Haematologic adverse reactions
- Hepatotoxicity
- Cardiovascular events
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