Kyprolis 60 Mg/50 Ml 60 mg/50 ml Powder for solution for infusion
PDF Leaflet Revision Date: 01 March 2024
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of relapsed or refractory multiple myeloma.
Dosage (summary)
IV infusion, starting at 20 mg/mu00b2, increased to 27 mg/mu00b2 or 56 mg/mu00b2 based on regimen.
Special Populations
- Renal impairment
- Hepatic impairment
- Elderly patients
Pregnancy & Breastfeeding
Not recommended during pregnancy or breastfeeding.
Key Drug Interactions
- Dexamethasone
- Lenalidomide
- Daratumumab
Contraindications
- Hypersensitivity to carfilzomib
- Breastfeeding
Common side effects
- Anaemia
- Thrombocytopenia
- Neutropenia
- Nausea
- Fatigue
Counselling Points
- Hydration required before treatment
- Monitor for infusion reactions
- Use effective contraception during treatment
Serious warnings
- Cardiac failure
- Pulmonary toxicity
- Acute renal failure
- Tumor lysis syndrome
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