Siroxtrin 125, 250 & 500 125mg, 250 mg & 500 mg Dispersible tablets
PDF Leaflet Revision Date: 17 June 2024
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of chronic iron overload due to blood transfusions and non-transfusion-dependent thalassemia.
Dosage (summary)
Starting dose: 20 mg/kg for transfusion overload; 10 mg/kg for non-transfusion-dependent thalassemia.
Special Populations
- Elderly patients
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
Not recommended during pregnancy; breastfeeding not advised.
Key Drug Interactions
- NSAIDs
- Corticosteroids
- Oral bisphosphonates
- Anticoagulants
- Repaglinide
- CYP3A4 substrates
Contraindications
- Hypersensitivity to deferasirox
- Creatinine clearance < 60 ml/min
- Severe hepatic impairment
- Pregnancy and lactation
Common side effects
- Gastrointestinal disturbances
- Skin rash
- Increased blood creatinine
Counselling Points
- Take on an empty stomach
- Monitor for signs of GI bleeding
- Regular serum ferritin monitoring
Serious warnings
- Risk of gastrointestinal ulceration and hemorrhage
- Hepatic failure reports
- Caution in elderly patients
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