Prandin 1 mg and 2 mg Vaginal Gel
PDF Leaflet Revision Date: 31 January 2025
Clinical Summary
Quick overview from the medicine insert
Indication
Induction of labour in at-term or near-term pregnant patients.
Dosage (summary)
Initial dose: 1 mg into the vaginal canal; may repeat with 1 or 2 mg after 6 hours, max 3 mg.
Special Populations
- Cardiovascular impairment
- Hepatic impairment
- Renal impairment
- Asthma
Pregnancy & Breastfeeding
Use with caution; monitor for uterine activity and fetal heart rate.
Key Drug Interactions
- Concurrent use with oxytocin not recommended
- Exogenous prostaglandin therapy may enhance response
Contraindications
- Hypersensitivity to PGE2
- Grand multiparity
- Previous uterine surgery
- Cephalopelvic disproportion
- Foetal heart rate compromise
- Obstetric conditions favoring surgical intervention
- Unexplained vaginal discharge or bleeding
Common side effects
- Altered fetal heart rate patterns
- Nausea
- Vomiting
- Diarrhoea
- Back pain
- Uterine hypercontractility
- Fever
Counselling Points
- Monitor for signs of hypertonus
- Report any unusual pain or fetal distress
- Follow dosing instructions carefully
Serious warnings
- Continuous monitoring of uterine activity and fetal heart rate recommended
- Risk of uterine rupture with excessive activity
- Caution in patients with ruptured membranes
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