Grantryl 1 mg/1 ml & 3 mg/3 ml Injection

Indication

Management of nausea and vomiting induced by chemotherapy, radiotherapy, and post-operative.

Dosage (summary)

Adults: 1-3 mg IV prior to chemotherapy/radiotherapy; max 9 mg/24h. PONV: 1 mg IV prior to anesthesia.

Special Populations

• Elderly
• Renal impairment
• Hepatic impairment

Pregnancy & Breastfeeding

Contraindicated during pregnancy and lactation.

Key Drug Interactions

• Phenobarbital may increase clearance
• Co-administer with benzodiazepines and neuroleptics

Contraindications

• Hypersensitivity
• Children under 2 years
• Congenital long QT syndrome

Common side effects

• Headache
• Dizziness
• Somnolence
• Abdominal pain
• Constipation

Counselling Points

• Avoid driving if somnolence occurs
• Report any signs of myocardial ischemia