Betacin 25 mg Capsule

Indication

Indometacin is indicated for the treatment of inflammatory conditions such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis, as well as for the management of acute pain and dysmenorrhea.

Dosage (summary)

The usual adult dosage is 25 mg to 50 mg taken orally two to three times daily, depending on the severity of the condition and the patient's response to treatment.

Onset of Action / Duration

The onset of action is typically within 1 to 2 hours after oral administration, with peak effects occurring within 2 to 4 hours.

Special Populations

• Elderly patients may require dose adjustments due to increased sensitivity and potential for adverse effects.
• Patients with renal impairment should use Indometacin with caution and may require dose adjustments.
• Patients with hepatic impairment may also need dose adjustments and close monitoring.

Pregnancy & Breastfeeding

Indometacin is contraindicated during the third trimester of pregnancy due to the risk of premature closure of the ductus arteriosus. Caution is advised during the first and second trimesters. It is excreted in breast milk; therefore, caution should be exercised when administering to nursing mothers.

Key Drug Interactions

• Concurrent use with other NSAIDs may increase the risk of gastrointestinal bleeding.
• May enhance the effects of anticoagulants such as warfarin.
• Use with caution in combination with antihypertensive agents as Indometacin may reduce their effectiveness.

Contraindications

• Hypersensitivity to Indometacin or any of its components.
• Active peptic ulcer disease or history of recurrent ulceration.
• Severe renal impairment.
• Severe hepatic impairment.
• Pregnancy (third trimester).

Common side effects

• Gastrointestinal disturbances such as nausea, vomiting, and abdominal pain.
• Headache and dizziness.
• Increased risk of cardiovascular events.
• Renal impairment.
• Skin reactions such as rash or pruritus.

Counselling Points

• Take Indometacin with food or milk to minimize gastrointestinal irritation.
• Do not exceed the recommended dose or duration of therapy without consulting a healthcare provider.
• Report any signs of gastrointestinal bleeding, such as black stools or vomiting blood, immediately.
• Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.