Parofor Crypto 140 Mg Oral Solution

Reduction in the occurrence of diarrhoea due to diagnosed Cryptosporidium parvum.

50 mg of paromomycin sulphate /kg BW /day for 7 consecutive days, i.e. 2.5 ml of product / 10 kg BW/day for 7 consecutive days. The consecutive treatment should be done at the same time each day. On farms with a history of cryptosporidiosis confirmed by positive oocyst count, treat all newborn calves on that farm before the age of 48 hours.

Do not use in animals with known hypersensitivity to paromomycin, other aminoglycosides or any of the excipients. Do not use in cases with impaired function of the kidneys or liver. Do not use in ruminating animals.

Special warnings for each target species
Animals should receive enough colostrum according to good breeding practice. Calves should only receive the product upon confirmation of cryptosporidium oocysts in their faeces and before the onset of diarrhoea.

Special precautions for use in animals
Since the product is potentially ototoxic and nephrotoxic, it is recommended to assess kidney function. Special care should be taken when considering administration of the product to new-born animals due to the known higher gastrointestinal absorption of paromomycin in neonates. This higher absorption could lead to an increased risk of oto- and nephrotoxicity. The use of the product in neonates should be based on a benefit/risk assessment by the responsible veterinarian.

Withdrawal Period(s)
Meat and offal: 62 days

Special precautions to be taken by the person administering PAROFOR 140 ORAL SOLUTION to animals
People with known hypersensitivity (allergy) to paromomycin or any other aminoglycosides should avoid contact with the product. Avoid contact with the skin and eyes. Personal protective equipment consisting of protective clothing and impervious gloves should be worn when handling the veterinary medicinal product.

In the event of accidental contact with the skin or eyes, rinse with plenty of clean water and seek medical attention of irritation persists. If you develop symptoms following exposure, such as skin rash, you should seek medical advice and show the physician this warning. Swelling of the face, lips and eyes or difficulty in breathing are more serious symptoms and require urgent medical attention. Do not eat, drink and smoke when handling the product. Do not ingest. In case of accidental ingestion, seek medical advice immediately and show the label to the physician. Wash hands after use.

General anaesthetics and muscle relaxing products increase the neuro-blocking effect of aminoglycosides. This may cause paralysis and apnoea. Do not use concurrently with strong diuretics and potentially oto- or nephrotoxic substances.

The safety of the product has not been established in pregnant or lactating cattle. This product is only indicated for use in pre-ruminant calves. Therefore, the use of the product is not recommended in these animals.

On rare occasions, soft faeces have been observed. Aminoglycoside antibiotics such as paromomycin can cause oto- and nephrotoxicity.

Do not administer for more than 7 days. In 2 to 5 week old calves, overdoses in excess of 50 mg paromomycin sulphate/kg bodyweight may induce gastrointestinal lesions (ulceration, pustules, chronic hyperplastic inflammation) mostly in the rumen and reticulum. Bruxism and poor appetite have been reported. Repeated overdose may be associated with death.