Altirem Injection

Indication

Induction and maintenance of general anesthesia, analgesia during surgery, and for sedation in intensive care settings.

Dosage (summary)

Administered as an intravenous infusion or injection, typically starting at a rate of 0.05 to 0.1 mcg/kg/min, adjusted according to the patient's response and clinical situation.

Onset of Action / Duration

Onset of action is within 1-2 minutes, with a duration of effect of approximately 5-10 minutes after discontinuation.

Special Populations

• Elderly patients may require dose adjustments.
• Patients with hepatic impairment may have altered pharmacokinetics.
• Patients with renal impairment may require careful monitoring.

Pregnancy & Breastfeeding

Remifentanil should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution is advised during lactation as it is not known if it is excreted in human milk.

Key Drug Interactions

• May interact with other central nervous system depressants, leading to increased sedation.
• Opioid analgesics may enhance the effects of remifentanil.

Contraindications

• Hypersensitivity to remifentanil or any component of the formulation.
• Severe respiratory depression.
• Acute or severe bronchial asthma.

Common side effects

• Respiratory depression.
• Hypotension.
• Nausea and vomiting.
• Bradycardia.

Counselling Points

• Inform patients about the potential for respiratory depression and the need for monitoring during and after administration.
• Advise patients to report any unusual symptoms or side effects immediately.