Zobone Solution For Infusion 5 mL
PDF Leaflet Revision Date: 10 August 2022
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of tumour-induced hypercalcaemia and skeletal conditions in advanced malignancies.
Dosage (summary)
4 mg IV infusion every 3-4 weeks, diluted in 100 mL saline or glucose.
Onset of Action / Duration
Onset: 2-3 months
Special Populations
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
Contraindicated in pregnancy and breastfeeding; safety not established.
Key Drug Interactions
- Aminoglycosides
- Calcitonin
- Loop diuretics
- Thalidomide
Contraindications
- Hypersensitivity to zoledronic acid
- Severe renal impairment
- Pregnancy
- Lactation
Common side effects
- Bone pain
- Fever
- Fatigue
- Nausea
- Hypocalcaemia
Counselling Points
- Maintain hydration
- Monitor renal function
- Report any oral symptoms
- Supplement calcium and vitamin D
Serious warnings
- Renal dysfunction
- Osteonecrosis of the jaw
- Atypical femur fractures
Important Disclaimer
The Zobone Solution For Infusion 5 mL professional information leaflet below is the property of Ranbaxy Pharmaceuticals and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
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