Abikem 250mg Tablet
PDF Leaflet Revision Date: 15 March 2022
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of metastatic castration-resistant prostate cancer.
Dosage (summary)
1,000 mg (four 250 mg tablets) once daily, taken without food.
Special Populations
- Hepatic impairment
- Renal impairment
Pregnancy & Breastfeeding
Contraindicated in pregnancy and lactation; may harm a developing fetus.
Key Drug Interactions
- Avoid strong CYP3A4 inducers
- Contraindicated with rifampicin
Contraindications
- Hypersensitivity
- Pregnancy
- Moderate to severe hepatic impairment
- Concomitant use with Ra-223
Common side effects
- Fluid retention
- Hypokalaemia
- Hypertension
- Increased liver enzymes
Counselling Points
- Take at least 2 hours after eating
- Monitor for signs of liver toxicity
- Use condoms if sexually active with women of childbearing age
Serious warnings
- May cause hypertension, hypokalaemia, fluid retention
- Risk of hepatotoxicity
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