Adcetris 50 mg Powder for concentrate for solution for infusion.

Indication

Treatment of CD30 positive cancers including Hodgkin lymphoma and systemic anaplastic large cell lymphoma.

Dosage (summary)

1.2 mg/kg IV infusion every 2 weeks for frontline HL; 1.8 mg/kg every 3 weeks for relapsed HL and sALCL.

Onset of Action / Duration

Onset: 30 mins, Duration: up to 16 cycles.

Special Populations

• Renal impairment
• Hepatic impairment

Pregnancy & Breastfeeding

Contraindicated in pregnancy and breastfeeding; men advised not to father a child during treatment and for 6 months after.

Key Drug Interactions

• CYP3A4 inhibitors/inducers
• Doxorubicin
• Vinblastine
• Dacarbazine

Contraindications

• Hypersensitivity
• Pregnancy
• Breastfeeding
• Combined use with bleomycin

Common side effects

• Neutropenia
• Peripheral neuropathy
• Nausea
• Fatigue
• Diarrhoea

Counselling Points

• Monitor for signs of infection
• Report any neurological symptoms
• Avoid pregnancy during treatment