Aggrastet Injection

Indication

Used for the prevention of thrombotic events in patients with acute coronary syndrome and those undergoing percutaneous coronary intervention.

Dosage (summary)

The recommended dose is an initial bolus of 0.4 mcg/kg/min for 30 minutes, followed by a continuous infusion of 0.1 mcg/kg/min.

Onset of Action / Duration

Onset of action is typically within 30 minutes, with effects lasting for several hours after discontinuation.

Special Populations

• Elderly patients
• Patients with renal impairment
• Patients with hepatic impairment

Pregnancy & Breastfeeding

Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution is advised during lactation.

Key Drug Interactions

• Increased risk of bleeding when used with anticoagulants such as heparin or warfarin.
• May interact with antiplatelet agents like aspirin and clopidogrel.

Contraindications

• Active bleeding or bleeding disorders
• Severe thrombocytopenia
• History of hypersensitivity to Tirofiban or any component of the formulation

Common side effects

• Bleeding complications
• Thrombocytopenia
• Nausea
• Headache
• Hypotension

Counselling Points

• Inform patients about the signs of bleeding and to report any unusual bruising or bleeding immediately.
• Advise patients to avoid activities that may increase the risk of injury.
• Discuss the importance of adherence to follow-up appointments and monitoring.