Aldurazyme Injection
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of mucopolysaccharidosis type I (MPS I) in patients with a confirmed diagnosis.
Dosage (summary)
The recommended dosage is 0.58 mg/kg body weight administered as an intravenous infusion once a week.
Onset of Action / Duration
The onset of therapeutic effects may vary; however, some patients may begin to notice improvements within a few weeks of starting treatment.
Special Populations
- Pediatric patients
- Geriatric patients
- Patients with renal impairment
- Patients with hepatic impairment
Pregnancy & Breastfeeding
Laronidase should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution is advised when administering to nursing mothers.
Key Drug Interactions
- No specific drug interactions have been reported; however, caution is advised when used with other medications that may affect immune function.
Contraindications
- Hypersensitivity to Laronidase or any of its excipients
- Severe allergic reactions
Common side effects
- Infusion-related reactions (e.g., fever, chills, rash)
- Headache
- Nausea
- Abdominal pain
- Fatigue
Counselling Points
- Inform patients about the potential for infusion-related reactions and the importance of reporting any unusual symptoms during or after infusion.
- Advise patients to maintain regular follow-up appointments for monitoring.
- Encourage patients to report any signs of allergic reactions.
Serious warnings
- Monitor for signs of hypersensitivity reactions during and after infusion.
- Use with caution in patients with a history of severe allergic reactions.
- Patients should be premedicated with antihistamines or corticosteroids if they have a history of infusion-related reactions.
Important Disclaimer
The Aldurazyme Injection professional information leaflet below is the property of Sanofi-Aventis South Africa and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
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