Austell Metoclopramide 5 mg/mL Injection

Indication

Nausea and vomiting associated with chemotherapy, surgery, or radiation therapy; gastroparesis; and as an adjunct in the treatment of gastroesophageal reflux disease (GERD).

Dosage (summary)

Adults: 10 mg (2 mL) administered by slow intravenous injection or infusion, up to 3 times daily. For children, dosage should be determined by a healthcare professional based on weight.

Onset of Action / Duration

Onset of action is typically within 30 to 60 minutes, with a duration of effect lasting up to 2 hours.

Special Populations

• Elderly patients
• Patients with renal impairment
• Patients with hepatic impairment

Pregnancy & Breastfeeding

Metoclopramide should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk; caution is advised when administered to nursing mothers.

Key Drug Interactions

• May enhance the effects of central nervous system depressants.
• Anticholinergic drugs may reduce the effectiveness of metoclopramide.
• Concurrent use with drugs that increase gastrointestinal motility may lead to additive effects.

Contraindications

• Hypersensitivity to metoclopramide or any component of the formulation.
• Pheochromocytoma.
• Gastrointestinal obstruction, perforation, or hemorrhage.
• Seizure disorders.

Common side effects

• Drowsiness
• Fatigue
• Restlessness
• Extrapyramidal symptoms
• Diarrhea

Counselling Points

• Advise patients to avoid driving or operating heavy machinery until they know how metoclopramide affects them.
• Inform patients about the potential for extrapyramidal symptoms and the importance of reporting any unusual movements or symptoms.
• Encourage patients to maintain hydration, especially if experiencing nausea or vomiting.