Cotellic 20 Mg 20 mg FC tablets
PDF Leaflet Revision Date: 15 March 2023
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of unresectable or metastatic melanoma with BRAF V600 mutation.
Dosage (summary)
60 mg (3 tablets) once daily for 21 days, followed by a 7-day break.
Special Populations
- Geriatric use
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
Not recommended during pregnancy; contraindicated in breastfeeding.
Key Drug Interactions
- CYP3A inhibitors
- CYP3A inducers
Contraindications
- Hypersensitivity to cobimetinib or excipients
Common side effects
- Diarrhea
- Nausea
- Vomiting
- Rash
- Photosensitivity
Counselling Points
- Avoid sun exposure
- Use effective contraception
- Monitor for visual disturbances
Serious warnings
- New primary malignancies
- Severe dermatologic reactions
- Haemorrhage
- Left ventricular dysfunction
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