Denlazyd 50/100 mg XR tablets
PDF Leaflet Revision Date: 06 May 2025
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of major depressive disorder.
Dosage (summary)
50 mg once daily, max 100 mg/day; adjust gradually.
Special Populations
- Renal impairment
- Hepatic impairment
- Elderly patients
Pregnancy & Breastfeeding
Contraindicated in pregnancy and lactation.
Key Drug Interactions
- MAOIs
- CNS-active medicines
- Alcohol
Contraindications
- Hypersensitivity
- MAOI use
- Children under 18
- Pregnancy
- Lactation
Common side effects
- Nausea
- Dizziness
- Insomnia
- Fatigue
- Dry mouth
Counselling Points
- Monitor for worsening depression
- Avoid alcohol
- Gradual dose tapering recommended
Serious warnings
- Risk of suicidality
- Serotonin syndrome
- Increased blood pressure
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