Eprolep Cr 200mg. 300mg. 500mg FC tablets
PDF Leaflet Revision Date: 30 March 2022
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of generalized and partial epilepsy, and mania in bipolar disorder.
Dosage (summary)
Start at 600 mg/day, increase by 200 mg every 3 days; max 2500 mg/day.
Onset of Action / Duration
Onset: 1-4 hours, Duration: 15 hours
Special Populations
- Elderly patients
- Renal impairment
Pregnancy & Breastfeeding
Contraindicated in pregnancy and lactation due to risk of fetal malformations.
Key Drug Interactions
- Increases phenobarbital and primidone levels
- Decreases phenytoin levels
- Potentiates effects of neuroleptics and benzodiazepines
Contraindications
- Hypersensitivity to sodium valproate
- Liver disease
- Urea cycle disorders
- Concurrent use with MAOIs
- Pregnancy and lactation
Common side effects
- Thrombocytopenia
- Somnolence
- Nausea
- Abdominal pain
- Weight gain
Counselling Points
- Monitor for liver function and blood counts
- Avoid abrupt discontinuation
- Use effective contraception in women of childbearing potential
Serious warnings
- Severe liver damage
- Pancreatitis
- Suicidal ideation
Important Disclaimer
The Eprolep Cr 200mg. 300mg. 500mg FC tablets professional information leaflet below is the property of Brimpharm Sa and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
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