Glucovance 1.25mg. 250mg Tablet

Glucovance 1.25mg. 250mg Tablet

S3
PDF Leaflet Revision Date: 23 July 2010

API: Glibenclamide Metformin | Company: Merck

Clinical Summary

Quick overview from the medicine insert

Indication

Type 2 diabetes management as initial or second-line therapy.

Dosage (summary)

Start with 1 tablet of Glucovance 250 mg/1.25 mg daily; adjust based on response.

Special Populations

  • Elderly
  • Renal impairment
  • Hepatic impairment

Pregnancy & Breastfeeding

Not recommended during pregnancy or lactation.

Key Drug Interactions

  • Miconazole
  • Fluconazole
  • Phenylbutazone
  • Diuretics
  • ACE-inhibitors

Contraindications

  • Hypersensitivity to components
  • Type 1 diabetes
  • Renal disease
  • Liver disease
  • Acute alcohol intoxication

Common side effects

  • Hypoglycaemia
  • Nausea
  • Vomiting
  • Diarrhoea
  • Abdominal pain

Counselling Points

  • Take with meals
  • Monitor blood glucose regularly
  • Avoid alcohol
  • Recognize hypoglycaemia symptoms

Serious warnings

  • Lactic acidosis
  • Risk of cardiovascular mortality
  • Hypoglycaemia symptoms

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Glucovance 1.25mg. 250mg Tablet
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