Grantryl 1 mg & 2 mg FC tablets
PDF Leaflet Revision Date: 24 November 2022
Clinical Summary
Quick overview from the medicine insert
Indication
Prevention of acute and delayed nausea and vomiting associated with chemotherapy and radiotherapy.
Dosage (summary)
1 mg twice daily or 2 mg once daily for up to one week post-chemotherapy; 2 mg once daily for up to one week post-radiotherapy.
Onset of Action / Duration
Onset: 1 hour before therapy, Duration: up to 1 week
Special Populations
- Geriatrics
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
Not recommended during pregnancy or lactation due to insufficient safety data.
Key Drug Interactions
- Serotonergic medicines
- Buprenorphine/opioids
- Phenobarbitone
- Ketoconazole
Contraindications
- Hypersensitivity to granisetron
- Children under 2 years
- Congenital long QT syndrome
Common side effects
- Headache
- Constipation
- Dizziness
- QT prolongation
Counselling Points
- Monitor for signs of serotonin syndrome
- Avoid driving until effects are known
- Correct electrolyte imbalances before use
Serious warnings
- Risk of serotonin syndrome
- QT interval prolongation
- Lower bowel motility reduction
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