A-Lennon Vitamin B Complex Injection

A-LENNON VITAMIN B COMPLEX INJECTION is indicated as a dietary supplement where a deficiency of vitamins exists.

Deficiency can be reversed by thiamine in doses as small as 500 u03bcg daily. A therapeutic dose of 1 to 2 ml daily is recommended. A-LENNON VITAMIN B COMPLEX INJECTION 2 ml: IM or slowly and with caution IV. A-LENNON VITAMIN B COMPLEX INJECTION 10 ml: For IM use only. A-LENNON VITAMIN B COMPLEX INJECTION must be injected slowly.

A-LENNON VITAMIN B COMPLEX INJECTION is contraindicated in patients with hypersensitivity to any of the active ingredients (see COMPOSITION).

Thiamine hydrochloride: Hypersensitivity reactions have occurred with thiamine, mainly after parenteral doses. These reactions have ranged in severity from very mild to, very rarely, fatal anaphylactic shock.

Pyridoxine: Effects of levodopa are reversed by pyridoxine (even doses as low as 5 mg daily). Pyridoxine supplements should be avoided (see INTERACTIONS).

Riboflavin: Large doses of riboflavin result in a bright yellow discolouration of the urine that may interfere with certain laboratory tests.

Effects on ability to drive and use machines: Since adverse reactions such as dizziness and blurred vision have been reported in patients receiving A-LENNON VITAMIN B COMPLEX INJECTION, patients should not drive, use machinery or perform any tasks that require concentration, until they are certain that A-LENNON VITAMIN B COMPLEX INJECTION does not adversely affect their ability to do so (see SIDE EFFECTS).

Thiamine hydrochloride:

• Alcohol: excessive alcohol intake induces thiamine deficiency.
• Furosemide: may increase urinary loss of thiamine; prolonged furosemide therapy may induce thiamine deficiency.

d-Panthenol:

• Alcohol: excessive alcohol intake may increase requirement for pantothenic acid.
• Oral contraceptives: may increase requirement for pantothenic acid.

Pyridoxine hydrochloride:

• Alcohol: increases turnover of pyridoxine.
• Anti-epileptic medication: enzyme-inducing anti-epileptic medicines (phenytoin, carbamazepine) may cause pyridoxine deficiency.
• Cycloserine: may cause anaemia or peripheral neuritis by acting as pyridoxine antagonist.
• Hydralazine: may cause anaemia or peripheral neuritis by acting as pyridoxine antagonist.
• Isoniazid: may cause anaemia or peripheral neuritis by acting as pyridoxine antagonist.
• Levodopa: effects of levodopa are reversed by pyridoxine (even doses as low as 5 mg daily). Pyridoxine supplements should be avoided (see WARNINGS AND SPECIAL PRECAUTIONS).
• Oestrogens: (including oral contraceptives) may increase requirement for pyridoxine.
• Penicillamine: may cause anaemia or peripheral neuritis by acting as pyridoxine antagonist.
• Theophylline: may increase requirement for pyridoxine.

Riboflavin:

• Alcohol: excessive alcohol intake induces riboflavin deficiency.
• Barbiturates: prolonged use may induce riboflavin deficiency.
• Oral contraceptives: prolonged use may induce riboflavin deficiency.
• Phenothiazines: may increase the requirement for riboflavin.
• Probenecid: reduces gastrointestinal absorption and urinary excretion of riboflavin.
• Tricyclic antidepressants: may increase the requirement for riboflavin.

The safety of A-LENNON VITAMIN B COMPLEX INJECTION in pregnancy and lactation has not been established. No adverse effects have been noted at recommended doses. However, animal studies are insufficient with respect to effects on pregnancy, embryonal/foetal development, parturition and/or postnatal development. Thiamine crosses the placenta and is excreted in breast milk. Pyridoxine appears in breast milk. Large doses may result in pyridoxine dependency in infants.

A-LENNON VITAMIN B COMPLEX INJECTION is usually well tolerated.

Nervous system disorders: Less frequent: paraesthesia

Vascular disorders: Less frequent: hypotension

General disorders and administrative site conditions: Less frequent: injection site reactions (including pain and swelling)

Nicotinamide: Chronic administration of large doses may cause:

Nervous system disorders: Less frequent: headache

Eye disorders: Less frequent: blurred vision

Respiratory, thoracic and mediastinal disorders: Less frequent: sore throat

Gastrointestinal disorders: Less frequent: nausea, heartburn

Skin and subcutaneous tissue disorders: Less frequent: dry skin, dry hair

General disorders and administrative site conditions: Less frequent: headaches, fatigue, sore throat, dry hair

Thiamine hydrochloride: Immune system disorders: Less frequent: hypersensitivity reactions, anaphylactic reactions (coughing, difficulty in breathing and swallowing, flushing, skin rash, swelling of face, lips and eyelids) (see WARNINGS AND SPECIAL PRECAUTIONS)

d-Panthenol: Gastrointestinal disorders: Less frequent: diarrhoea

Pyridoxine: Adverse effects usually occur with large doses only. Doses of 100 u2013 150 mg daily over 5-10 years has not generally been associated with toxicity.

Riboflavin: Riboflavin toxicity is unknown in humans. Renal and urinary disorders: Less frequent: yellow discolouration of the urine (see WARNINGS AND SPECIAL PRECAUTIONS)

A-LENNON VITAMIN B COMPLEX INJECTION contains water-soluble vitamins which are readily excreted. In the event of an overdosage, treatment is symptomatic and supportive.