Pifeltro 100 Mg FC Tablet 100mg Tablet
PDF Leaflet Revision Date: 17 June 2025
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of HIV-1 in adults and adolescents aged 12 years and older without NNRTI resistance.
Dosage (summary)
100 mg orally once daily; adjust to twice daily with rifabutin or moderate CYP3A inducers.
Special Populations
- Elderly
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
Use during pregnancy is not recommended; avoid breastfeeding due to potential HIV transmission.
Key Drug Interactions
- Strong CYP3A inducers
- Rifabutin
- St. John's wort
Contraindications
- Hypersensitivity to doravirine or excipients
- Co-administration with strong CYP3A inducers
Common side effects
- Nausea
- Headache
- Fatigue
- Rash
Counselling Points
- Take once daily with or without food
- Do not double dose if missed
- Report any unusual mood changes or rash
Serious warnings
- Risk of immune reactivation syndrome
- Caution in severe hepatic impairment
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