Prograf 0.5mg / 1mg / 5mg capsules
PDF Leaflet Revision Date: 24 April 2020
Clinical Summary
Quick overview from the medicine insert
Indication
Primary immunosuppression in organ transplant recipients.
Dosage (summary)
Initial oral dose: 0.1-0.4 mg/kg/day in two divided doses.
Special Populations
- Liver impairment
- Kidney impairment
- Elderly patients
- Paediatric patients
Pregnancy & Breastfeeding
Contraindicated in pregnancy and breastfeeding.
Key Drug Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
- CYP3A4 inducers (e.g., rifampicin, St. John's Wort)
- Ciclosporin
Contraindications
- Hypersensitivity to tacrolimus
- Pregnancy and lactation
- Concomitant use with live vaccines
Common side effects
- Infections
- Hypertension
- Diabetes mellitus
- Renal impairment
- Tremor
Counselling Points
- Take on an empty stomach for better absorption.
- Monitor for signs of infection.
- Avoid grapefruit juice.
Serious warnings
- Risk of infections and malignancies
- Careful monitoring required
- Not recommended for children under 18
Important Disclaimer
The Prograf 0.5mg / 1mg / 5mg capsules professional information leaflet below is the property of Astellas and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
Healthcare Professionals Only
This content is for registered healthcare professionals
Sign in or create a free account to read the full package insert.
Free for HPCSA-registered professionals. Powered by Medinsert.
