P&U Etoposide 100mg / 5ml Injection

Indication

Treatment of testicular tumors and small-cell lung carcinoma.

Dosage (summary)

50 to 120 mg/mu00b2 daily for 5 days; 100 mg/mu00b2 on alternate days.

Onset of Action / Duration

Onset: Not specified, Duration: Terminal half-life ~8 hours.

Special Populations

• Severe hepatic dysfunction
• Children

Pregnancy & Breastfeeding

Contraindicated in pregnancy and lactation; potential fetal harm.

Key Drug Interactions

• Caution with other myelosuppressive agents

Contraindications

• Hypersensitivity to Etoposide
• Severe hepatic dysfunction
• Severe myelosuppression
• Acute infections

Common side effects

• Nausea
• Vomiting
• Leucopenia
• Thrombocytopenia
• Alopecia

Counselling Points

• Use effective contraception during treatment
• Monitor for signs of myelosuppression
• Avoid extravasation during administration