Macaine Hcl 0,5 % Spinal Injection With Dextrose 5 mg/mL Spinal injection
PDF Leaflet Revision Date: 27 October 2025
Clinical Summary
Quick overview from the medicine insert
Indication
Spinal anaesthesia for surgery.
Dosage (summary)
2-4 mL (10-20 mg) for adults.
Onset of Action / Duration
Onset: 10-15 mins, Duration: 2-3 hours.
Special Populations
- Elderly
- Pregnant women
- Patients with cardiovascular impairment
Pregnancy & Breastfeeding
Not recommended in early pregnancy; reduced dose in late pregnancy; minimal risk during breastfeeding.
Key Drug Interactions
- Other local anaesthetics
- Antidysrhythmics (e.g., amiodarone)
Contraindications
- Hypersensitivity to bupivacaine
- Active CNS disease
- Spinal stenosis
- Coagulation disorders
Common side effects
- Hypotension
- Nausea
- Postdural puncture headache
- Urinary retention
Counselling Points
- Monitor for signs of toxicity
- Ensure IV access before administration
- Avoid in early pregnancy
Serious warnings
- Risk of systemic toxicity
- Cardiovascular and respiratory depression
- Neurological injury
Important Disclaimer
The Macaine Hcl 0,5 % Spinal Injection With Dextrose 5 mg/mL Spinal injection professional information leaflet below is the property of Adcock Ingram Critical Care and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
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