Donepezil Unicorn 5 and 10 mg Tablets
PDF Leaflet Revision Date: 25 April 2024
Clinical Summary
Quick overview from the medicine insert
Indication
Symptomatic treatment of mild to moderate dementia in Alzheimer's disease.
Dosage (summary)
Initial: 5 mg once daily; may increase to 10 mg after 4-6 weeks if needed.
Special Populations
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
Not established; contraindicated in pregnancy and breastfeeding.
Key Drug Interactions
- Anticholinergics
- Cholinergic agonists
- NSAIDs
- QTc prolonging drugs
Contraindications
- Hypersensitivity to donepezil
- Pregnancy
- Lactation
- Children
- Post-surgery recovery
Common side effects
- Nausea
- Diarrhoea
- Insomnia
- Fatigue
- Agitation
Counselling Points
- Take in the evening
- Monitor for side effects
- Avoid abrupt discontinuation
Serious warnings
- Monitor for bradycardia
- Risk of gastrointestinal bleeding
- Potential for neuroleptic malignant syndrome
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