Depreta 30 mg and 60 mg CAPSULES
PDF Leaflet Revision Date: 15 December 2020
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of depression and diabetic peripheral neuropathic pain.
Dosage (summary)
60 mg once daily for adults; 30 mg once daily for mild to moderate renal impairment.
Special Populations
- Renal impairment
- Hepatic impairment
- Elderly
Pregnancy & Breastfeeding
Contraindicated in pregnancy and breastfeeding.
Key Drug Interactions
- MAOIs
- CYP1A2 inhibitors
- CYP2D6 inhibitors
Contraindications
- Hypersensitivity to duloxetine
- Severe hepatic impairment
- Advanced renal impairment
- Concomitant use of MAOIs
- Children under 18 years
Common side effects
- Nausea
- Headache
- Dry mouth
- Somnolence
- Dizziness
Counselling Points
- Avoid abrupt discontinuation
- Monitor for suicidal thoughts
- Caution with alcohol and CNS depressants
Serious warnings
- Increased risk of suicidal thoughts
- Serotonin syndrome
- Hypertension
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