Mezibe Plus 10 mg and 10 mg, 10 mg and 20 mg, Tablets
PDF Leaflet Revision Date: 29 August 2023
Clinical Summary
Quick overview from the medicine insert
Indication
Adjunctive therapy for primary hypercholesterolaemia and mixed hyperlipidaemia.
Dosage (summary)
Start at 10/20 mg/day; max 10/80 mg/day for hypercholesterolaemia.
Special Populations
- Elderly
- Hepatic impairment
- Renal impairment
Pregnancy & Breastfeeding
Contraindicated in pregnancy and lactation.
Key Drug Interactions
- CYP3A4 inhibitors
- Fibrates
- Gemfibrozil
- Amiodarone
- Verapamil
Contraindications
- Hypersensitivity
- Active liver disease
- Moderate to severe hepatic impairment
- Pregnancy
- Lactation
- Children
Common side effects
- Headache
- Abdominal pain
- Diarrhoea
- Myopathy
- Rhabdomyolysis
Counselling Points
- Take in the evening
- Report muscle pain or weakness
- Avoid grapefruit juice
- Monitor for liver function
Serious warnings
- Risk of myopathy/rhabdomyolysis
- Monitor liver enzymes
- Avoid potent CYP3A4 inhibitors
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