Arthrexin 100mg Suppositories
Clinical Summary
Quick overview from the medicine insert
Indication
Management of pain and inflammation associated with conditions such as arthritis, gout, and other musculoskeletal disorders.
Dosage (summary)
The usual adult dosage is 50 mg to 100 mg administered rectally, up to three times daily, as needed.
Onset of Action / Duration
Onset of action typically occurs within 30 minutes to 1 hour, with duration of effect lasting up to 6-8 hours.
Special Populations
- Elderly patients
- Patients with renal impairment
- Patients with hepatic impairment
- Patients with cardiovascular disease
Pregnancy & Breastfeeding
Indomethacin should be avoided during pregnancy, especially in the third trimester, and should be used with caution during lactation as it may pass into breast milk.
Key Drug Interactions
- Anticoagulants (increased risk of bleeding)
- Other NSAIDs (increased risk of gastrointestinal side effects)
- Diuretics (may reduce effectiveness)
- Lithium (may increase lithium levels)
Contraindications
- Active gastrointestinal bleeding or ulceration
- Severe renal impairment
- Severe hepatic impairment
- Hypersensitivity to indomethacin or other NSAIDs
- History of asthma exacerbated by NSAIDs
Common side effects
- Gastrointestinal discomfort
- Nausea and vomiting
- Headache
- Dizziness
- Rash
- Increased blood pressure
Counselling Points
- Take with food to minimize gastrointestinal irritation.
- Do not exceed the recommended dosage.
- Report any signs of gastrointestinal bleeding (e.g., black stools, vomiting blood).
- Inform healthcare provider of any other medications being taken.
- Avoid alcohol to reduce the risk of gastrointestinal side effects.
Serious warnings
- Use with caution in patients with a history of gastrointestinal disease.
- Monitor renal function in long-term use.
- May cause cardiovascular events; use the lowest effective dose for the shortest duration.
- Discontinue use if signs of severe skin reactions occur.
Important Disclaimer
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