Arthrexin 25mg or 50 mg Capsules

Indication

Indomethacin is indicated for the treatment of inflammatory conditions such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and acute gouty arthritis.

Dosage (summary)

The usual adult dosage is 25 mg to 50 mg taken two to three times daily, depending on the severity of the condition.

Onset of Action / Duration

The onset of action is typically within 1 to 2 hours, with peak effects occurring within 2 to 4 hours.

Special Populations

• Elderly patients may require dose adjustments due to increased sensitivity.
• Patients with renal impairment should use with caution and may require dose adjustments.
• Patients with hepatic impairment should use with caution.

Pregnancy & Breastfeeding

Indomethacin is classified as Category C for pregnancy. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk; caution is advised when administered to nursing mothers.

Key Drug Interactions

• May interact with anticoagulants, increasing the risk of bleeding.
• Concurrent use with other NSAIDs may increase the risk of gastrointestinal side effects.
• May reduce the effectiveness of antihypertensive medications.

Contraindications

• Hypersensitivity to indomethacin or any of its components.
• Active peptic ulcer disease.
• Severe renal or hepatic impairment.
• History of gastrointestinal bleeding or perforation related to previous NSAID therapy.

Common side effects

• Gastrointestinal disturbances (nausea, vomiting, diarrhea, constipation).
• Headache and dizziness.
• Increased blood pressure.
• Rash and other allergic reactions.

Counselling Points

• Take with food or milk to minimize gastrointestinal irritation.
• Do not exceed the recommended dose.
• Report any signs of gastrointestinal bleeding (e.g., black stools, vomiting blood).
• Inform healthcare provider of any other medications being taken.