Vulante FC tablets
PDF Leaflet Revision Date: 03 October 2024
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of HIV-1 infection in adults.
Dosage (summary)
One tablet orally once daily, regardless of food.
Special Populations
- Elderly
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
Use during pregnancy may increase risk of neural tube defects; not recommended during breastfeeding.
Key Drug Interactions
- Rifampicin decreases dolutegravir levels
- Metformin increases risk of lactic acidosis
Contraindications
- Hypersensitivity to components
- Moderate/severe hepatic impairment
- Renal impairment (creatinine clearance < 80 mL/min)
- Patients < 18 years
- Pregnant or breastfeeding women
Common side effects
- Neutropenia
- Anemia
- Nausea
- Diarrhea
- Fatigue
Counselling Points
- Advise on potential side effects
- Importance of adherence to therapy
- Regular monitoring of liver and renal function
Serious warnings
- Lactic acidosis and severe hepatomegaly reported
- Risk of hypersensitivity reactions
- Immune reconstitution inflammatory syndrome (IRIS)
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