Warfarin Tablets
Clinical Summary
Quick overview from the medicine insert
Indication
Prevention and management of thromboembolic disorders.
Dosage (summary)
Initial: 10-15 mg/day for 3 days; Maintenance: 2.5-10 mg/day.
Onset of Action / Duration
Onset: 2-8 hours, Duration: 2-5 days
Special Populations
- Elderly
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
Avoid in pregnancy and lactation; teratogenic effects.
Key Drug Interactions
- NSAIDs
- Amiodarone
- Vitamin K
- Barbiturates
Contraindications
- Hypersensitivity to warfarin
- Bleeding disorders
- Pregnancy
- Severe liver or renal impairment
Common side effects
- Haemorrhage
- Alopecia
- Nausea
- Vomiting
Counselling Points
- Importance of compliance
- Carry anticoagulant alert card
- Discuss lifestyle modifications
Serious warnings
- Abrupt cessation not advisable
- Requires monitoring of prothrombin time
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