Aspen Pravastatin Tablets
Clinical Summary
Quick overview from the medicine insert
Indication
Hyperlipidemia management and cardiovascular risk reduction.
Dosage (summary)
Initial dose of 10 mg to 40 mg once daily, taken in the evening.
Onset of Action / Duration
Lipid-lowering effects may be observed within 1 to 2 weeks, with maximum effect typically seen after 4 to 6 weeks.
Special Populations
- Elderly patients
- Patients with renal impairment
- Patients with hepatic impairment
Pregnancy & Breastfeeding
Pravastatin is contraindicated during pregnancy and lactation due to potential harm to the fetus and nursing infant.
Key Drug Interactions
- Increased risk of myopathy with concomitant use of other lipid-lowering agents.
- Caution with drugs that inhibit CYP3A4, such as certain antifungals and antibiotics.
- May interact with anticoagulants, increasing the risk of bleeding.
Contraindications
- Active liver disease
- Pregnancy
- Breastfeeding
- Hypersensitivity to pravastatin or any component of the formulation
Common side effects
- Muscle pain or weakness
- Gastrointestinal disturbances (e.g., nausea, diarrhea)
- Headache
- Elevated liver enzymes
Counselling Points
- Advise patients to report any unexplained muscle pain or weakness.
- Instruct on the importance of adherence to diet and lifestyle changes.
- Inform patients to take the medication in the evening for optimal efficacy.
- Discuss potential side effects and the need for regular follow-up blood tests.
Serious warnings
- Monitor liver function tests before and during treatment.
- Use with caution in patients with a history of liver disease.
- Risk of diabetes may be increased with statin use.
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