Ativan Injection 1 ml Injection

Indication

Management of anxiety disorders, preoperative sedation, and as an adjunct in the treatment of status epilepticus.

Dosage (summary)

Initial dose of 1-2 mg IV, may be repeated every 4-6 hours as needed, not to exceed 10 mg/day.

Onset of Action / Duration

Onset of action is typically within 15-30 minutes; duration of effect is approximately 6-8 hours.

Special Populations

• Elderly patients
• Patients with hepatic impairment
• Patients with renal impairment

Pregnancy & Breastfeeding

Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Lorazepam is excreted in breast milk; caution is advised when administered to nursing mothers.

Key Drug Interactions

• CNS depressants (e.g., alcohol, opioids) may enhance sedative effects.
• CYP3A4 inhibitors may increase lorazepam levels.
• CYP3A4 inducers may decrease lorazepam levels.

Contraindications

• Hypersensitivity to lorazepam or any component of the formulation.
• Severe respiratory insufficiency.
• Sleep apnea syndrome.

Common side effects

• Drowsiness
• Dizziness
• Confusion
• Ataxia
• Hypotension

Counselling Points

• Avoid alcohol and other CNS depressants while taking lorazepam.
• Do not abruptly discontinue use after prolonged therapy to avoid withdrawal symptoms.
• Inform healthcare provider if pregnant, planning to become pregnant, or breastfeeding.