Dacin 200 200 mg Lyophilised powder for I.V. injection
PDF Leaflet Revision Date: 3 January 2025
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of metastatic malignant melanoma, metastatic sarcoma, and Hodgkinu2019s disease.
Dosage (summary)
2-4.5 mg/kg/day for 10 days, repeated every 3 weeks.
Special Populations
- Pregnant women
- Breastfeeding women
- Severe liver disease
- Severe kidney disease
Pregnancy & Breastfeeding
Contraindicated in pregnancy and breastfeeding due to mutagenic and teratogenic risks.
Key Drug Interactions
- Live-attenuated vaccines
- Phenytoin
- Oral anticoagulants
- Ciclosporin
- Fotemustine
Contraindications
- Hypersensitivity to dacarbazine
- Leukopenia
- Thrombocytopenia
- Pregnancy
- Breastfeeding
Common side effects
- Nausea
- Vomiting
- Anaemia
- Leukopenia
- Thrombocytopenia
Counselling Points
- Avoid food before administration
- Use effective contraception during treatment
- Monitor for signs of liver dysfunction
Serious warnings
- Severe gastrointestinal disturbances
- Hepatotoxicity
- Immunosuppression
- Risk of veno-occlusive disease
Important Disclaimer
The Dacin 200 200 mg Lyophilised powder for I.V. injection professional information leaflet below is the property of Key Oncologics and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
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