Kez 20 mg. Solution.
PDF Leaflet Revision Date: 07 February 2023
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of essential hypertension.
Dosage (summary)
One tablet once daily; starting dose 40/5 mg, max 80/10 mg.
Onset of Action / Duration
Onset: 3 hours, Duration: 24 hours
Special Populations
- Renal impairment
- Hepatic impairment
- Elderly (> 65 years)
Pregnancy & Breastfeeding
Not recommended during pregnancy or lactation.
Key Drug Interactions
- Concomitant use with ACE inhibitors or ARBs
- Grapefruit juice may increase amlodipine effects
- Lithium may increase toxicity
Contraindications
- Hypersensitivity to components
- Severe renal impairment
- Severe hepatic impairment
- Bilateral renal artery stenosis
Common side effects
- Dizziness
- Hypotension
- Peripheral edema
Counselling Points
- Monitor blood pressure regularly
- Avoid grapefruit juice
- Report any signs of hypotension
Serious warnings
- Risk of hypotension in volume-depleted patients
- Dual blockade of RAAS increases adverse effects
Important Disclaimer
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