Lenacapavir 300 Mg Tablet Gilead 300 mg FC tablet
PDF Leaflet Revision Date: 14 October 2025
Clinical Summary
Quick overview from the medicine insert
Indication
Pre-exposure prophylaxis (PrEP) for sexually acquired HIV-1.
Dosage (summary)
Initiation: Day 1 - 927 mg subcutaneous + 600 mg oral; Day 2 - 600 mg oral. Maintenance: 600 mg oral every 6 months.
Special Populations
- Elderly
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
Considered safe during pregnancy; low levels in breast milk, no adverse effects observed in infants.
Key Drug Interactions
- Strong inducers of CYP3A
- St. John's wort
- Carbamazepine
- Phenytoin
Contraindications
- Hypersensitivity
- Unknown HIV-1 status
Counselling Points
- Confirm HIV-1 negative status before initiation
- Importance of adherence to dosing schedule
- Use safer sex practices
Serious warnings
- Risk of HIV-1 acquisition if not adherent to dosing schedule
- Potential for resistance development
Important Disclaimer
The Lenacapavir 300 Mg Tablet Gilead 300 mg FC tablet professional information leaflet below is the property of Gilead Sciences South Africa and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
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