Leponex 25mg. 100mg Tablet
PDF Leaflet Revision Date: 11 August 2006
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment-resistant schizophrenia and reducing risk of suicidal behavior.
Dosage (summary)
Starting at 12.5 mg, titrate to 300-450 mg/day; max 900 mg/day.
Special Populations
- Elderly
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
Use in pregnancy only if benefits outweigh risks; avoid breastfeeding.
Key Drug Interactions
- CYP450 inhibitors/inducers
- Benzodiazepines
- Alcohol
Contraindications
- Hypersensitivity to clozapine
- History of agranulocytosis
- Uncontrolled epilepsy
Common side effects
- Sedation
- Weight gain
- Tachycardia
- Constipation
Counselling Points
- Monitor for infections
- Avoid activities requiring alertness
- Regular blood tests required
Serious warnings
- Risk of agranulocytosis
- Orthostatic hypotension
- Seizures
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