Lorien 20 mg Capsules
PDF Leaflet Revision Date: 27 June 2021
Clinical Summary
Quick overview from the medicine insert
Indication
Indicated for major depressive episodes, bulimia nervosa, and obsessive-compulsive disorder.
Dosage (summary)
Adults: 20 mg daily, up to 80 mg if necessary. Bulimia: 60 mg daily. OCD: 20-60 mg daily.
Special Populations
- Elderly
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
Caution in pregnancy; potential risks include cardiovascular defects and PPHN. Safety in lactation not established.
Key Drug Interactions
- Monoamine oxidase inhibitors
- Tamoxifen
- Metoprolol
- Serotonergic medicines
Contraindications
- Hypersensitivity to fluoxetine
- Severe renal failure
- Children
Common side effects
- Headache
- Nausea
- Insomnia
- Fatigue
- Diarrhoea
Counselling Points
- Monitor for suicidal thoughts
- Avoid abrupt discontinuation
- Report any distressing symptoms
Serious warnings
- Risk of suicidal thoughts
- Serotonin syndrome
- Withdrawal symptoms
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