Macropen 250 mg Capsules and Macropen powder for suspension
PDF Leaflet Revision Date: 30 January 2026
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of bacterial infections caused by susceptible organisms.
Dosage (summary)
Adults: 500 mg three times daily.
Special Populations
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
Safety in pregnancy not established; excreted in breast milk.
Key Drug Interactions
- Anticoagulants
- Allopurinol
- Paracetamol
Contraindications
- Hypersensitivity to penicillins
- History of jaundice with flucloxacillin
- Neonates
Common side effects
- Allergic reactions
- Diarrhoea
- Nausea
- Vomiting
Counselling Points
- Take on an empty stomach
- Monitor for allergic reactions
- Consider alternative contraception
Serious warnings
- Serious hypersensitivity reactions
- Risk of superinfection
- Convulsions in renal impairment
Important Disclaimer
The Macropen 250 mg Capsules and Macropen powder for suspension professional information leaflet below is the property of Viatris South Africa and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
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