Navalzyd 300 mg, 400 mg & 1 g Solution for infusion or injection
PDF Leaflet Revision Date: 23 August 2024
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of generalized and partial epilepsy, and mania in bipolar disorder.
Dosage (summary)
Adults: 400-800 mg IV over 3-5 mins, max 2500 mg/day. Replace with oral therapy as soon as possible.
Special Populations
- Elderly
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
High teratogenic risk; contraindicated in pregnancy and lactation.
Key Drug Interactions
- Carbapenems
- Phenobarbital
- Lamotrigine
- Oestrogen-containing products
Contraindications
- Hypersensitivity
- Active liver disease
- Mitochondrial disorders
- Urea cycle disorders
Common side effects
- Weight gain
- Drowsiness
- Nausea
- Diarrhea
- Tremor
Counselling Points
- Use effective contraception
- Monitor for liver function
- Report signs of pancreatitis
- Do not stop abruptly
Serious warnings
- Risk of liver failure
- Pancreatitis
- Suicidal ideation
- Aggravated convulsions
Important Disclaimer
The Navalzyd 300 mg, 400 mg & 1 g Solution for infusion or injection professional information leaflet below is the property of Abex Pharmaceutica and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
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