Rubilim Cr 200/ Cr 300 &Amp, Cr 500 200mg. 300mg. 500mg Tablet
PDF Leaflet Revision Date: 06 April 2022
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of generalized and partial epilepsy, and mania in bipolar disorder.
Dosage (summary)
Adults: Start at 600 mg/day, increase by 200 mg every 3 days; max 2500 mg/day. Children: 20 mg/kg/day, adjust as needed.
Special Populations
- Elderly
- Renal impairment
- Paediatric population
Pregnancy & Breastfeeding
Contraindicated in pregnancy and lactation; high teratogenic risk.
Key Drug Interactions
- Increased sedation with phenobarbitone
- Decreased efficacy with carbapenem antibiotics
- Increased toxicity with lamotrigine
Contraindications
- Hypersensitivity to sodium valproate
- Active liver disease
- Mitochondrial disorders
- Pregnancy
Common side effects
- Headache
- Nausea
- Dizziness
- Weight gain
- Thrombocytopenia
Counselling Points
- Monitor for signs of liver damage
- Avoid alcohol
- Use effective contraception in women of childbearing potential
Serious warnings
- Risk of hepatotoxicity
- Suicidal ideation
- Pancreatitis
Important Disclaimer
The Rubilim Cr 200/ Cr 300 &Amp, Cr 500 200mg. 300mg. 500mg Tablet professional information leaflet below is the property of Ruby Pharmaceuticals and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
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