Sinemet 25mg. 100mg, 25mg. 250mg Tablet
PDF Leaflet Revision Date: 18 June 2015
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of Parkinson's disease and syndrome.
Dosage (summary)
Initial: 1 tablet of SINEMET 25/100 three times daily; max: 8 tablets/day.
Onset of Action / Duration
Onset: 1 day, Duration: up to 8 hours.
Special Populations
- Renal impairment
- Hepatic impairment
- Cardiovascular disease
Pregnancy & Breastfeeding
Use in pregnancy only if benefits outweigh risks; levodopa excreted in breast milk.
Key Drug Interactions
- Antihypertensives
- MAO inhibitors
- Iron supplements
Contraindications
- Hypersensitivity
- Narrow angle glaucoma
- Malignant melanoma
Common side effects
- Dyskinesias
- Nausea
- Confusion
- Depression
Counselling Points
- Monitor for sudden sleep onset
- Avoid abrupt discontinuation
- Regular skin checks recommended
Serious warnings
- Risk of melanoma
- Monitor for impulse control disorders
- Caution in cardiovascular disease
Important Disclaimer
The Sinemet 25mg. 100mg, 25mg. 250mg Tablet professional information leaflet below is the property of Organon South Africa and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
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