Sinemet Cr 50mg. 200mg Tablet
PDF Leaflet Revision Date: 20 May 1998
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of Parkinson's disease and syndrome.
Dosage (summary)
Initial: 1 tablet 2-3 times daily; max 600 mg levodopa/day.
Onset of Action / Duration
Onset: 30 mins, Duration: 4-6 hours
Special Populations
- Renal impairment
- Hepatic impairment
- Cardiovascular disease
Pregnancy & Breastfeeding
Use only if benefits outweigh risks; levodopa excreted in breast milk.
Key Drug Interactions
- Antihypertensives
- Antidepressants
- Iron supplements
Contraindications
- Nonselective MAO inhibitors
- Hypersensitivity
- Narrow angle glaucoma
- History of melanoma
Common side effects
- Dyskinesia
- Nausea
- Hallucinations
- Confusion
- Dizziness
Counselling Points
- Avoid abrupt discontinuation
- Monitor for dyskinesias
- Caution with driving
Serious warnings
- Risk of melanoma
- Monitor for impulse control disorders
- Caution in psychosis
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