Sirturo 100 mg Tablets
PDF Leaflet Revision Date: 18 May 2021
Clinical Summary
Quick overview from the medicine insert
Indication
For multi-drug resistant pulmonary tuberculosis in adults.
Dosage (summary)
Weeks 1-2: 400 mg once daily; Weeks 3-24: 200 mg three times per week.
Special Populations
- Hepatic impairment
- Renal impairment
- Elderly
Pregnancy & Breastfeeding
Safety not established; avoid breastfeeding.
Key Drug Interactions
- CYP3A4 inducers
- CYP3A4 inhibitors
- QT prolonging medications
Contraindications
- Hypersensitivity to bedaquiline
- Congenital QT prolongation
- Uncontrolled cardiac dysrhythmias
- Severe hepatic impairment
Common side effects
- Nausea
- Headache
- Dizziness
- Vomiting
- Arthralgia
Counselling Points
- Take with food
- Adhere to dosing schedule
- Report any dizziness or cardiac symptoms
Serious warnings
- QT prolongation
- Increased mortality in trials
- Monitor electrolytes
Important Disclaimer
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