Tazatred 20/50/70/100 20 mg, 50 mg, 70 mg, 100 mg Tablet
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of adults with Ph+ CML and Ph+ ALL.
Dosage (summary)
100 mg once daily for chronic phase CML; 70 mg twice daily for advanced phase CML or Ph+ ALL.
Special Populations
- Renal impairment
- Hepatic impairment
- Elderly population
Pregnancy & Breastfeeding
Not recommended in pregnancy; contraindicated in breastfeeding.
Key Drug Interactions
- CYP3A4 inhibitors
- CYP3A4 inducers
- H2 antagonists
- Proton pump inhibitors
Contraindications
- Hypersensitivity to dasatinib
- Concomitant use of H2 antagonists or PPIs
Common side effects
- Myelosuppression
- Fluid retention
- Cardiac adverse reactions
Counselling Points
- Take consistently with or without food
- Monitor for signs of bleeding
- Use contraception during treatment
Serious warnings
- Myelosuppression
- Severe bleeding events
- Pulmonary arterial hypertension
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