Toplep 25/50/100/200 25mg/50mg/100mg/200mg Tablet. Oral Solution
PDF Leaflet Revision Date: 16 May 2022
Clinical Summary
Quick overview from the medicine insert
Indication
Monotherapy and adjunctive therapy for epilepsy.
Dosage (summary)
Adults: Start at 25-50 mg nightly, titrate to 200-400 mg/day; max 800 mg. Children: Start at 25 mg, titrate to 5-9 mg/kg/day.
Special Populations
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
Teratogenic effects in animals; use only if benefits outweigh risks. Excretion in breast milk not well studied.
Key Drug Interactions
- Phenytoin
- Carbamazepine
- Valproic acid
- Oral contraceptives
- Lithium
Contraindications
- Hypersensitivity
- Children under 2 years
- Pregnancy
Common side effects
- Drowsiness
- Dizziness
- Nausea
- Weight loss
- Mood disturbances
Counselling Points
- Monitor for mood changes
- Stay hydrated
- Avoid CNS depressants
- Gradual withdrawal recommended
Serious warnings
- Acute myopia and glaucoma
- Metabolic acidosis
- Hyperammonemia
- Suicidal ideation
Important Disclaimer
The Toplep 25/50/100/200 25mg/50mg/100mg/200mg Tablet. Oral Solution professional information leaflet below is the property of Ranbaxy Pharmaceuticals {Pty) Ltd and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
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