Trilef 400mg, 300 mg, 300 mg Tablet
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of HIV-1 in adults over 18 years.
Dosage (summary)
One tablet daily on an empty stomach; bedtime dosing recommended.
Special Populations
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
Contraindicated in pregnancy and breastfeeding.
Key Drug Interactions
- CYP450 inducers/inhibitors
- St. John's wort
- Terfenadine
Contraindications
- Hypersensitivity
- Severe hepatic impairment
- Moderate to severe renal impairment
- Pregnancy
- Lactation
Common side effects
- Dizziness
- Nausea
- Rash
- Fatigue
Counselling Points
- Take on an empty stomach
- Monitor for liver function
- Use barrier contraception
Serious warnings
- Lactic acidosis
- Severe hepatotoxicity
- Immune reconstitution inflammatory syndrome
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