Unisim 10 mg, 20 mg, 40 mg FC tablets.
PDF Leaflet Revision Date: 10 May 2023
Clinical Summary
Quick overview from the medicine insert
Indication
Hypercholesterolaemia and coronary heart disease.
Dosage (summary)
Initial dose: 10 mg daily in the evening for hypercholesterolaemia; 20 mg daily for coronary heart disease.
Special Populations
- Renal impairment
- Elderly
Pregnancy & Breastfeeding
Contraindicated in pregnancy and lactation.
Key Drug Interactions
- CYP3A4 inhibitors
- Gemfibrozil
- Ciclosporin
Contraindications
- Hypersensitivity to simvastatin
- Liver disease
- Pregnancy
- Lactation
Common side effects
- Myalgia
- Muscle cramps
- Nausea
- Headache
Counselling Points
- Report unexplained muscle pain
- Avoid grapefruit juice
- Monitor liver function tests
Serious warnings
- Risk of myopathy and rhabdomyolysis
- Liver function abnormalities
Important Disclaimer
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