Zyloprim Tablets
PDF Leaflet Revision Date: 15 February 2022
Clinical Summary
Quick overview from the medicine insert
Indication
Management of hyperuricemia and gout-related conditions.
Dosage (summary)
Start at 100 mg/day, usual maintenance 300 mg/day; max 900 mg/day.
Special Populations
- Elderly
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
Not established for pregnancy; contraindicated in breastfeeding.
Key Drug Interactions
- 6-Mercaptopurine
- Azathioprine
- Diuretics
- ACE inhibitors
Contraindications
- Hypersensitivity to allopurinol
- Severe hepatic or renal disorder
- Acute gout attack
Common side effects
- Nausea
- Diarrhoea
- Rash
- Hypersensitivity reactions
Counselling Points
- Take after meals for GI tolerance
- Hydrate adequately
- Monitor for skin reactions
Serious warnings
- Risk of SJS/TEN
- Monitor renal function
- Avoid in acute gout attacks
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